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Sadie Bennett, Arzu Cubukcu, Chun Wai Wong, Timothy Griffith, Cheryl Oxley, Diane Barker, Simon Duckett, Duwarakan Satchithananda, Ashish Patwala, Grant Heatlie, and Chun Shing Kwok

–70% of elderly lymphoma patients in other studies ( 3 , 4 ). Although these treatments have led to improved survival rates in cancer patients, their side effects are known to increase morbidity and mortality either via cardiotoxicity or the accelerated

Open access

Adrienn Tarr, Stephan Stoebe, Jan Tuennemann, Zsuzsanna Baka, Dietrich Pfeiffer, Albert Varga, and Andreas Hagendorff

Introduction Cardiotoxicity is the most important side effect of anthracycline and other chemicals affecting the myocardium. It is well known that anthracyclines and trastuzumab induce left ventricular dysfunction. Two types of cardiotoxicity are

Open access

Kevin Emery Boczar, Olexiy Aseyev, Jeffrey Sulpher, Christopher Johnson, Ian G Burwash, Michele Turek, Susan Dent, and Girish Dwivedi

imaging (strain, strain rate imaging), as recommended in the recent multimodality guidelines to detect subclinical LV dysfunction, may provide evidence of associated right ventricular cardiotoxicity ( 8 ). In our study, we hypothesized that breast cancer

Open access

Carolyn M Larsen and Sharon L Mulvagh

cardiotoxicity of common chemotherapeutic agents associated with an increased risk for left ventricular systolic dysfunction and to outline an approach to the clinical assessment and management of patients at risk for cardiotoxicity from these agents, with a

Open access

Tan Suwatanaviroj, Weimin He, Edith Pituskin, Ian Paterson, Jonathan Choy, and Harald Becher

Introduction Serial measurements of left ventricular (LV) ejection fraction (EF) are commonly performed in cancer patients to monitor cardiotoxic effects of chemotherapy. Similarly, patients with other cardiac conditions, including valvular

Open access

A King, J Thambyrajah, E Leng, and M J Stewart

). Herceptin is a monoclonal antibody treatment used in Her2+ve breast cancer either as monotherapy or more commonly, in combination with anthracycline. The cardiotoxic side effects of Herceptin are well established and therefore cardiac monitoring, usually by

Open access

Rebecca Dobson, Arjun K Ghosh, Bonnie Ky, Tom Marwick, Martin Stout, Allan Harkness, Rick Steeds, Shaun Robinson, David Oxborough, David Adlam, Susannah Stanway, Bushra Rana, Thomas Ingram, Liam Ring, Stuart Rosen, Chris Plummer, Charlotte Manisty, Mark Harbinson, Vishal Sharma, Keith Pearce, Alexander R Lyon, Daniel X Augustine, and the British Society of Echocardiography (BSE) and the British Society of Cardio-Oncology (BCOS)

RV assessment should be used in the echocardiographic assessment of these patients. The clinical implications of a significant decline in GLS with potentially cardiotoxic cancer therapy require further investigation. Advances in cancer

Open access

Guy Lloyd

. ( doi:10.1093/ehjci/jes140 ) 22833550 10.1093/ehjci/jes140 2 Martín M Esteva FJ Alba E Khandheria B Pérez-Isla L García-Sáenz JA Márquez A Sengupta P Zamorano J 2009 Minimizing cardiotoxicity while optimizing

Open access

Clare M Jackson, Helen E Ellis, Mark C Dodd, and Laurence O'Toole

(cardiac arrhythmia secondary to cardiac metastasis, embolisation of the tumour into a coronary artery and cardiotoxicity of doxorubicin chemotherapy), but none was considered to be able to comprehensively explain the absence of symptoms before the cardiac

Open access

Thomas Mathew, Lynne Williams, Govardhan Navaratnam, Bushra Rana, Richard Wheeler, Katherine Collins, Allan Harkness, Richard Jones, Dan Knight, Kevin O'Gallagher, David Oxborough, Liam Ring, Julie Sandoval, Martin Stout, Vishal Sharma, Richard P Steeds, and on behalf of the British Society of Echocardiography Education Committee

dysfunction has developed, the damage may be irreversible. Chemotherapeutic drugs such as trastuzumab (Herceptin), anthracyclines and cyclophosphamide are most commonly implicated in causing impaired LV function. Regular monitoring for cardiotoxicity with